Health & Research Goals
Neuro Focus
Enfoque Neuro
High-Performance Stack
Select a vial or the total
Primary Description
Semax elevates BDNF and supports neuroplasticity via the TrkB pathway. Selank modulates GABA and serotonin to reduce anxiety without sedation. Neither creates tolerance or dependence in laboratory models. A clean cognitive performance protocol.
Demonstrated Effects
- BDNF
- Neuroplasticity
- Anxiolytic
- Focus
Proposed Mechanisms of Action
Combined Mechanism
Semax (ACTH 4-10 analog, Met-Glu-His-Phe-Pro-Gly-Pro) increases BDNF (Brain-Derived Neurotrophic Factor) in the hippocampus and prefrontal cortex, enhancing synaptic plasticity, memory consolidation, and neuronal survival. It also modulates dopaminergic and serotonergic transmission to improve attention and executive function. Selank (tuftsin Thr-Lys-Pro-Arg-Pro-Gly-Pro analog) primarily modulates GABAergic tone to produce anxiolytic effects without sedation, while stabilizing enkephalin degradation for mood support. The combination delivers cognitive enhancement (Semax) with anxiolytic balance (Selank) — performance without overstimulation. Both peptides are validated for intranasal administration with CNS bioavailability confirmed in preclinical and clinical research.
Stack Compounds
Research Evidence & Clinical Data
Research Profile
Semax increases BDNF and supports neuroplasticity. Selank modulates GABA and serotonin for anxiety reduction without sedation. Neither causes tolerance or dependency.
Safety Profile
Common Side Effects
- Intranasal administration preferred — use proper nasal spray device
- Mild headache possible in first 1-2 days (BDNF upregulation adaptation)
- Selank may cause transient drowsiness at higher doses if not using intranasal route
- Do not combine with benzodiazepines or CNS depressants without medical supervision
Contraindications
- Severe anxiety disorder requiring pharmacological management (titrate carefully)
- Concomitant benzodiazepine therapy
- History of seizures
- Pregnancy
Analytical Quality Assurance
Research Protocols
Dosing Protocols
Combined Research Protocol: Enfoque Neuro
Sub-QMonitoring & Risk Management
Compound Stack Monitoring
For stacks and blends, refer to the individual compound monographs for each included ingredient for specific monitoring guidelines.